A total of 475 patients who were scheduled for cancer surgery and received CGA from January 2014 to June 2015 were included. This study evaluated the association between pre- operative medication use and post- operative delirium (POD) in surgical oncology patients receiving comprehensive geriatric assessment (CGA). Delirium is strongly associated with poor surgical outcomes. Older patients undergoing surgery tend to have a higher frequency of delirium. Jeong, Young Mi Lee, Eunsook Kim, Kwang-Il Chung, Jee Eun In Park, Hae Lee, Byung Koo Gwak, Hye Sun PMID:27175376Īssociation of pre- operative medication use with post- operative delirium in surgical oncology patients receiving comprehensive geriatric assessment. The implications of this viewpoint for clinical trials are discussed. Methods for using mathematical models of drug delivery and tumor response with imaging data to estimate patient-specific parameters that are needed for calculation of AUTOC are outlined. The mathematical analogy between response of observers to images and the response of tumors to distributions of a chemotherapy drug is exploited to obtain linear discriminant functions from which AUTOC can be calculated. In radiation therapy, AUTOC can be computed for a single patient by using image data along with radiobiological models for tumor response and adverse side effects. The area under a TOC curve (AUTOC) can be used as a figure of merit for therapeutic efficacy, analogous to the area under an ROC curve ( AUROC), which is a figure of merit for diagnostic efficacy. This paper shows how TOC can be applied to chemotherapy with the administered drug dosage as the variable. The therapy operating characteristic (TOC) curve, developed in the context of radiation therapy, is a plot of the probability of tumor control versus the probability of normal-tissue complications as the overall radiation dose level is varied, e.g., by varying the beam current in external-beam radiotherapy or the total injected activity in radionuclide therapy. Therapy operating characteristic curves: tools for precision chemotherapyīarrett, Harrison H.
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